甲状腺肿瘤中 microRNA 表达的失调。
Deregulation of microRNA expression in thyroid tumors.
机构信息
Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
出版信息
J Zhejiang Univ Sci B. 2014 Mar;15(3):212-24. doi: 10.1631/jzus.B1300192.
Abstract
MicroRNAs (miRNAs or miRs) are endogenous non-coding RNAs that negatively regulate gene expression by binding to the 3' non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expression profiles, single nucleotide polymorphism (SNP) in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.
摘要
微小 RNA（miRNAs 或 miRs）是内源性非编码 RNA，通过与靶 mRNAs 的 3'非编码区结合，负调控基因表达，导致其切割或阻断翻译。miRNAs 可能对细胞分化、增殖和存活有影响，其失调可能导致疾病和癌症，包括甲状腺肿瘤。本综述的目的是总结不同类型甲状腺肿瘤中失调 miRNAs 的现有研究结果，并展示其潜在的靶基因，特别是那些参与肿瘤侵袭和转移的基因。此外，本综述还包括循环 miRNA 表达谱、甲状腺肿瘤中单核苷酸多态性（SNP）以及体细胞突变与甲状腺肿瘤中失调 miRNA 表达的相关性的新发现。
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