Wonders Karen Y, Hydock David S, Greufe Stephanie, Schneider Carole M, Hayward Reid
Department of Health, Physical Education, and Recreation, Wright State University, Dayton, OH 45435, USA.
Cancer Chemother Pharmacol. 2009 Nov;64(6):1105-13. doi: 10.1007/s00280-009-0967-z. Epub 2009 Apr 8.
To determine if endurance exercise training performed prior to administration of the anticancer drugs DOX and GW2974 would be cardioprotective.
Rats remained sedentary or exercise trained for 10 weeks. Following the exercise or sedentary period, rats were randomly assigned to treatment groups. Rats in sedentary and exercise groups received saline or a combination of 10 mg/kg DOX and 30 mg/kg GW2974. Cardiac function was assessed 2, 5, or 10 days following treatments.
Sedentary animals receiving DOX/GW2974 experienced significant cardiac dysfunction. At 2-, 5-, and 10-days post, cardiac function in trained, drug-treated animals was significantly preserved. Additionally, animals exercised prior to DOX/GW2974 injections had significantly lower levels of myocardial lipid peroxidation and caspase-3 and -8 activities compared to their sedentary counterparts.
Exercise training protected against the cardiac dysfunction associated with DOX/GW2974 administration and may be related to an inhibition in apoptotic signaling.
确定在给予抗癌药物多柔比星（DOX）和GW2974之前进行耐力运动训练是否具有心脏保护作用。
大鼠保持久坐不动或进行10周的运动训练。在运动或久坐期之后，将大鼠随机分配至治疗组。久坐组和运动组的大鼠接受生理盐水或10mg/kg多柔比星与30mg/kg GW2974的组合。在治疗后2、5或10天评估心脏功能。
接受多柔比星/GW2974的久坐动物出现明显的心脏功能障碍。在给药后2天、5天和10天，经训练且接受药物治疗的动物的心脏功能得到显著保留。此外，与久坐的对应动物相比，在注射多柔比星/GW2974之前进行运动的动物的心肌脂质过氧化水平以及半胱天冬酶-3和-8活性显著降低。
运动训练可预防与多柔比星/GW2974给药相关的心脏功能障碍，这可能与凋亡信号传导的抑制有关。
