Hydock D S, Wonders K Y, Schneider C M, Hayward R
School of Sport and Exercise Science and the Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO, USA.
Prostate Cancer Prostatic Dis. 2006;9(4):392-8. doi: 10.1038/sj.pcan.4500890. Epub 2006 Jun 20.
This study examined the effects of an 8-week androgen deprivation therapy treatment using Zoladex and an endurance training regimen on cardiac function.
Male Sprague-Dawley rats received either Zoladex or placebo. Animals remained sedentary or endurance trained during the drug treatment period. On day 57, ex vivo cardiac function was analyzed.
Hearts from sedentary animals receiving Zoladex possessed significant cardiac dysfunction. However, hearts from exercise trained rats receiving Zoladex possessed cardiac function values similar to those from hearts from placebo animals.
An 8-week treatment with Zoladex promoted cardiac dysfunction. Endurance training during Zoladex treatment protected against this cardiac dysfunction.
本研究考察了使用诺雷德进行为期8周的雄激素剥夺疗法治疗以及耐力训练方案对心脏功能的影响。
雄性斯普拉格-道利大鼠接受诺雷德或安慰剂治疗。在药物治疗期间，动物保持久坐不动或进行耐力训练。在第57天，对离体心脏功能进行分析。
接受诺雷德治疗的久坐不动动物的心脏出现明显的心功能障碍。然而，接受诺雷德治疗的运动训练大鼠的心脏功能值与接受安慰剂治疗动物的心脏功能值相似。
使用诺雷德进行8周治疗会导致心脏功能障碍。在诺雷德治疗期间进行耐力训练可预防这种心脏功能障碍。
