Speich R, Jenni R, Opravil M, Pfab M, Russi E W
Department of Internal Medicine, University Hospital, Zürich, Switzerland.
Chest. 1991 Nov;100(5):1268-71. doi: 10.1378/chest.100.5.1268.
A prospective evaluation of 74 human immunodeficiency virus (HIV)-infected patients with cardiopulmonary complaints revealed six patients (8.1 percent) with pulmonary hypertension with elevated right ventricular systolic over right atrial pressure of 58 +/- 8 mm Hg (range, 49 to 66 mm Hg), as documented by Doppler echocardiography. A thromboembolic cause was excluded by normal lung perfusion scans. Electrocardiographic and roentgenographic features of pulmonary hypertension were present in five patients. Two patients died three and nine months after diagnosis of pulmonary hypertension. Autopsy revealed plexogenic pulmonary arteriopathy in both. The observation of six patients with primary pulmonary hypertension (PPH) in a cohort of 1,200 HIV-infected subjects corresponding to an incidence of 0.5 percent is striking and suggests a possible association of PPH with HIV infection.
对74例有心肺症状的人类免疫缺陷病毒（HIV）感染患者进行的前瞻性评估显示，有6例患者（8.1%）患有肺动脉高压，右心室收缩压高于右心房压力58±8毫米汞柱（范围为49至66毫米汞柱），经多普勒超声心动图证实。肺部灌注扫描正常排除了血栓栓塞原因。5例患者存在肺动脉高压的心电图和X线特征。2例患者在诊断为肺动脉高压后3个月和9个月死亡。尸检显示两人均有丛状肺血管病。在1200例HIV感染受试者队列中观察到6例原发性肺动脉高压（PPH）患者，发病率为0.5%，这一结果引人注目，提示PPH与HIV感染可能存在关联。
