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Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo.

作者信息

Yamamoto Koji, Takeshita Kyosuke, Kojima Tetsuhito, Takamatsu Junki

机构信息

Department of Transfusion Medicine, Cardiology and Hematology, Nagoya University Hospital, Nagoya, Japan.

Department of Transfusion Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya, 466-8560, Japan.

出版信息

Int J Hematol. 2009 May;89(4):553-554. doi: 10.1007/s12185-009-0305-6. Epub 2009 Apr 8.

DOI:10.1007/s12185-009-0305-6
PMID:19353236
Abstract
摘要

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1
Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo.匹伐他汀在体内可抑制应激诱导的纤溶酶原激活物抑制剂-1（PAI-1）表达。
Int J Hematol. 2009 May;89(4):553-554. doi: 10.1007/s12185-009-0305-6. Epub 2009 Apr 8.
2
Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells.
J Cell Biochem. 2003 Sep 1;90(1):23-32. doi: 10.1002/jcb.10602.
3
Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency.AT1a受体缺陷对血管紧张素II和去甲肾上腺素诱导的纤溶酶原激活物抑制剂-1表达的调节作用
Kidney Int. 2007 Jul;72(1):72-81. doi: 10.1038/sj.ki.5002268. Epub 2007 Apr 11.
4
Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes.贝特类药物抑制人脂肪细胞和前脂肪细胞纤溶酶原激活物抑制剂-1 的表达。
Thromb Haemost. 2009 Jun;101(6):1060-9.
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Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization.纤溶酶原激活物抑制剂-1的转基因过表达导致骨强度和矿化随年龄增长和性别特异性增加。
Bone. 2007 Dec;41(6):995-1004. doi: 10.1016/j.bone.2007.08.020. Epub 2007 Aug 17.
6
Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.纤溶酶原激活物抑制剂-1 通过抑制尿激酶型纤溶酶原激活物介导的纤溶酶原激活来保护小鼠免受心肌纤维化。
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Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice.匹伐他汀在体外的有益直接脂肪向性作用及其在肥胖小鼠中的表现。
Atherosclerosis. 2010 Sep;212(1):131-8. doi: 10.1016/j.atherosclerosis.2010.04.019. Epub 2010 Apr 21.
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Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs.纤溶酶原激活物抑制剂-1抑制纤维化肺成纤维细胞中的促纤维化反应。
J Biol Chem. 2015 Apr 10;290(15):9428-41. doi: 10.1074/jbc.M114.601815. Epub 2015 Feb 3.
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The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo.PAI-1 的生物化学、生理学和病理学作用，以及体内抑制 PAI-1 的要求。
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Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.纤溶酶原激活物抑制剂-1在小鼠体内脂肪组织中的分布与调节。肿瘤坏死因子-α和脂多糖的诱导作用。
J Clin Invest. 1996 Jan 1;97(1):37-46. doi: 10.1172/JCI118404.

本文引用的文献

1
Effect of oxidative stress on the expression of t-PA, u-PA, u-PAR, and PAI-1 in endothelial cells.氧化应激对内皮细胞中组织型纤溶酶原激活物（t-PA）、尿激酶型纤溶酶原激活物（u-PA）、尿激酶型纤溶酶原激活物受体（u-PAR）和纤溶酶原激活物抑制剂-1（PAI-1）表达的影响。
Biochem Cell Biol. 2008 Dec;86(6):477-86. doi: 10.1139/O08-137.
2
Immunohistochemical study on distribution of NF-kappaB and p53 in gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin.短暂性脑缺血后沙鼠海马中NF-κB和p53分布的免疫组织化学研究：匹伐他汀的作用
Metab Brain Dis. 2007 Mar;22(1):89-104. doi: 10.1007/s11011-006-9040-3. Epub 2007 Jan 17.
3
Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits.
阿托伐他汀可降低动脉粥样硬化兔脂肪组织中纤溶酶原激活物抑制剂-1的表达。
Clin Chim Acta. 2006 Aug;370(1-2):57-62. doi: 10.1016/j.cca.2006.01.024. Epub 2006 Feb 28.
4
HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons.HMG CoA还原酶抑制剂通过降低神经元的氧化应激反应来减轻Wistar大鼠的缺血性脑损伤。
Brain Res. 2005 Mar 10;1037(1-2):52-8. doi: 10.1016/j.brainres.2004.12.051.
5
Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method.采用DNA疫苗法制备的特异性抗体，通过酶免疫测定法检测小鼠纤溶酶原激活物抑制剂-1 。
Thromb Res. 2003;111(4-5):285-91. doi: 10.1016/j.thromres.2003.09.007.
6
Statins differ in their ability to block NF-kappaB activation in human blood monocytes.他汀类药物在阻断人血单核细胞中核因子κB激活的能力上存在差异。
Int J Clin Pharmacol Ther. 2003 Sep;41(9):397-401. doi: 10.5414/cpp41397.
7
Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells.
J Cell Biochem. 2003 Sep 1;90(1):23-32. doi: 10.1002/jcb.10602.
8
Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals.纤溶酶原激活物抑制剂-1是一种主要的应激调节基因：对老年个体应激诱导的血栓形成的影响。
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):890-5. doi: 10.1073/pnas.022608799. Epub 2002 Jan 15.
9
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins.3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂增加大鼠主动脉内皮细胞的纤溶活性。香叶基香叶基化和Rho蛋白的作用。
Circ Res. 1998 Oct 5;83(7):683-90. doi: 10.1161/01.res.83.7.683.
10
Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice.肥胖小鼠中纤溶酶原激活物抑制剂-1的组织分布与调控
Mol Med. 1996 Sep;2(5):568-82.