The Roxelyn and Richard Pepper Department of Communication Sciences, Northwestern University, Evanston, IL, USA.
J Autism Dev Disord. 2009 Aug;39(8):1185-96. doi: 10.1007/s10803-009-0737-0. Epub 2009 Apr 8.
This study provides new evidence of deficient auditory cortical processing of speech in noise in autism spectrum disorders (ASD). Speech-evoked responses (approximately 100-300 ms) in quiet and background noise were evaluated in typically-developing (TD) children and children with ASD. ASD responses showed delayed timing (both conditions) and reduced amplitudes (quiet) compared to TD responses. As expected, TD responses in noise were delayed and reduced compared to quiet responses. However, minimal quiet-to-noise response differences were found in children with ASD, presumably because quiet responses were already severely degraded. Moreover, ASD quiet responses resembled TD noise responses, implying that children with ASD process speech in quiet only as well as TD children do in background noise.
本研究为自闭症谱系障碍（ASD）患者在噪声环境中言语听觉皮层处理能力不足提供了新证据。本研究评估了正常发育（TD）儿童和 ASD 儿童在安静和背景噪声环境下的言语诱发反应（约 100-300ms）。与 TD 反应相比，ASD 反应的时间延迟（两种情况）和幅度降低（安静）。如预期的那样，与安静反应相比，TD 反应在噪声中的延迟和降低。然而，在 ASD 儿童中发现了最小的安静到噪声的反应差异，可能是因为安静反应已经严重降低。此外，ASD 的安静反应类似于 TD 的噪声反应，这意味着 ASD 儿童在安静环境中处理言语的能力与 TD 儿童在背景噪声中处理言语的能力一样差。
