非核苷类HIV-1逆转录酶抑制剂。第13部分：用于针对野生型菌株进行体外抗HIV评估的含氟二芳基三嗪衍生物的合成。
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.
作者信息
Xiong Yuan-Zhen, Chen Fen-Er, Balzarini Jan, De Clercq Erik, Pannecouque Christophe
机构信息
School of Pharmacy, Fudan University, Shanghai 200031, P. R. China.
出版信息
Chem Biodivers. 2009 Apr;6(4):561-8. doi: 10.1002/cbdv.200800163.
PMID:19353537
Abstract
A series of diaryltriazine derivatives modified at C(2) of the triazine ring with a fluorinated phenyl group has been synthesized and tested for the ability to inhibit HIV-1 replication. Most of these F-containing compounds showed low-to-moderate anti-HIV activity in MT-4 cells.
摘要
已经合成了一系列在三嗪环的C(2)位用氟化苯基修饰的二芳基三嗪衍生物，并测试了它们抑制HIV-1复制的能力。这些含氟化合物中的大多数在MT-4细胞中表现出低至中等的抗HIV活性。
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