Liu G, Yu C X
Gynecologic and Obstetrics Hospital, Shanghai Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1991 Sep;26(5):278-80, 322.
In the last decade, chorionic villi sampling (CVS) has been widely accepted as a new technique in prenatal diagnosis. An inconsistency in karyotypes between CVS and fetal tissue was found in clinical practice, although the chorionic villi and the fetal tissues were from the same fertilized ovum. Karyotypes from direct chromosomal preparation of chorionic villi and cultured fetal tissues in 52 artificial abortion samples were compared. Results showed two cases with karyotypic inconsistency: (1) 46, XX/46, XY in the chorionic villus direct preparation and 46, XX in the fetal tissue; (2) 46, XY in the direct preparation of chorionic villi and 45,XY, t (15q21q) de novo in the fetal tissue. Our research demonstrates that karyotype from chorionic villus direct preparation does not always reflect the fetal karyotype.
在过去十年中，绒毛取样（CVS）作为一种产前诊断新技术已被广泛接受。尽管绒毛和胎儿组织来自同一个受精卵，但在临床实践中发现CVS与胎儿组织的核型存在不一致。比较了52例人工流产样本中绒毛直接染色体制备和培养胎儿组织的核型。结果显示有两例核型不一致的情况：（1）绒毛直接制备的核型为46, XX/46, XY，而胎儿组织的核型为46, XX；（2）绒毛直接制备的核型为46, XY，而胎儿组织的核型为45, XY, t (15q21q) 新生。我们的研究表明，绒毛直接制备的核型并不总是反映胎儿核型。
