Silin Dmytro S, Lyubomska Oksana V, Ershov Feliks I, Frolov Valeriy M, Kutsyna Galyna A
Laboratory of Molecular Virology, Medical and Biology Center, School of Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Curr Pharm Des. 2009;15(11):1238-47. doi: 10.2174/138161209787846847.
Interferons are first immunomodulatory molecules that have been shown to display a wide range of applications due to their antiviral, antibacterial, antitumor, and inflammatory activities. Natural and recombinant interferons are among most common biologic therapeutics worldwide. Interferon inducers, however, are less known and have been mostly developed and used in former socialist countries. Despite the fact that they are virtually unknown to the Western world, they represent a substantial market share of modern pharmacopoeia in former socialist republics. This review provides a brief description of most popular interferon inducers including Amyxin, Amizon, Anandin, Arbidol, Blasten, Cycloferon, Galavit, Groprinosine, Hepon, Immunoxel, Dzherelo, Kagocel, Larifan, Ligfol, Likopid, Mebavin, MIGI-KLP, V-5 Immunitor, SCV-07, Milife, Neovir, Poludan, Ragocin, Ridostin, Thymogen and Savratz, some of which were in use for several decades for the same clinical indications as for interferons. The variety and choice offered by the pharmaceutical industry behind the former "iron curtain" certainly deserves the appreciation, familiarity and application prospects for medical and research investigators worldwide.
干扰素是首批免疫调节分子，因其具有抗病毒、抗菌、抗肿瘤和抗炎活性而显示出广泛的应用。天然干扰素和重组干扰素是全球最常见的生物治疗药物之一。然而，干扰素诱导剂鲜为人知，主要在前社会主义国家得到开发和应用。尽管西方世界对它们几乎一无所知，但它们在前社会主义共和国的现代药典中占有相当大的市场份额。本综述简要介绍了最常用的干扰素诱导剂，包括阿米辛、氨米佐、阿南定、阿比多尔、布拉斯坦、环芬、加拉维特、格罗普里诺辛、赫庞、免疫oxel、日热洛、卡古塞尔、拉里凡、利福尔、利科皮德、梅巴文、MIGI-KLP、V-5免疫增强剂、SCV-07、米利夫、新病毒、波卢丹、拉戈辛、利多斯汀、胸腺因子和萨夫拉茨，其中一些已用于相同临床适应症数十年，与干扰素的使用情况相同。前“铁幕”背后制药行业提供的品种和选择，无疑值得全球医学和研究人员欣赏、熟悉并关注其应用前景。
