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1
Natural killer T cells in the lungs of patients with asthma.哮喘患者肺部的自然杀伤T细胞。
J Allergy Clin Immunol. 2009 May;123(5):1181-5. doi: 10.1016/j.jaci.2009.02.013. Epub 2009 Apr 8.
2
Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma.变应原激发对特应性哮喘患者自然杀伤T细胞百分比的影响。
Ann Allergy Asthma Immunol. 2009 May;102(5):432-7. doi: 10.1016/s1081-1206(10)60517-0.
3
Activated CD8(+) T cells and NKT cells in BAL fluid improve diagnostic accuracy in sarcoidosis.BAL 液中活化的 CD8(+)T 细胞和 NKT 细胞可提高结节病的诊断准确性。
Lung. 2014 Feb;192(1):133-40. doi: 10.1007/s00408-013-9527-8. Epub 2013 Nov 10.
4
CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling.慢性嗜酸性粒细胞性肺部炎症需要CD4+细胞，但气道重塑则不需要。
Am J Physiol Lung Cell Mol Physiol. 2009 Feb;296(2):L229-35. doi: 10.1152/ajplung.90543.2008. Epub 2008 Dec 5.
5
Clinical significance of invariant natural killer T cells and IL-5 in acute eosinophilic pneumonia.不变自然杀伤T细胞和白细胞介素-5在急性嗜酸性粒细胞性肺炎中的临床意义
Allergol Int. 2021 Apr;70(2):258-261. doi: 10.1016/j.alit.2020.09.013. Epub 2020 Nov 13.
6
Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma.支气管肺泡灌洗术检测发现，哮喘患者体内的不变自然杀伤T细胞数量并未增加。
J Allergy Clin Immunol. 2007 May;119(5):1274-6. doi: 10.1016/j.jaci.2007.02.021. Epub 2007 Apr 2.
7
Innate immunity alterations in idiopathic interstitial pneumonias and rheumatoid arthritis-associated interstitial lung diseases.特发性间质性肺炎和类风湿关节炎相关间质性肺疾病中的先天性免疫改变。
Immunol Lett. 2015 Feb;163(2):179-86. doi: 10.1016/j.imlet.2014.12.004. Epub 2014 Dec 23.
8
Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma.变应性哮喘患者变应原激发后支气管肺泡灌洗液中37 kDa杀伤特异性分泌蛋白增加。
Clin Exp Allergy. 2005 May;35(5):643-9. doi: 10.1111/j.1365-2222.2005.02238.x.
9
α-Galactosylceramide-induced airway eosinophilia is mediated through the activation of NKT cells.α-半乳糖神经酰胺诱导的气道嗜酸性粒细胞增多是通过 NKT 细胞的激活介导的。
J Immunol. 2011 Apr 15;186(8):4687-92. doi: 10.4049/jimmunol.1003659. Epub 2011 Mar 7.
10
Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms.草花粉季节自然暴露于变应原对气道炎症细胞及哮喘症状的影响。
Thorax. 1996 Jun;51(6):575-81. doi: 10.1136/thx.51.6.575.

引用本文的文献

1
Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.解析哮喘中的固有淋巴细胞和固有样淋巴细胞：从途径到机制与治疗
J Biomed Sci. 2025 May 12;32(1):48. doi: 10.1186/s12929-025-01142-w.
2
Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies.自然杀伤 T 细胞在过敏性哮喘中的作用：对新型免疫治疗策略发展的启示。
Front Immunol. 2024 Apr 2;15:1364774. doi: 10.3389/fimmu.2024.1364774. eCollection 2024.
3
T-cell responses in asthma exacerbations.哮喘恶化中的 T 细胞反应。
Ann Allergy Asthma Immunol. 2022 Dec;129(6):709-718. doi: 10.1016/j.anai.2022.07.027. Epub 2022 Jul 30.
4
Type 2 and Type 17 Invariant Natural Killer T Cells Contribute to Local Eosinophilic and Neutrophilic Inflammation and Their Function Is Regulated by Mucosal Microenvironment in Nasal Polyps.2型和17型不变自然杀伤T细胞促成局部嗜酸性粒细胞和中性粒细胞炎症，且它们的功能受鼻息肉黏膜微环境调控。
Front Immunol. 2022 Jun 3;13:803097. doi: 10.3389/fimmu.2022.803097. eCollection 2022.
5
Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.自然杀伤 T 淋巴细胞整合先天感觉信息并将上下文传递给效应免疫应答。
Crit Rev Immunol. 2021;41(4):55-88. doi: 10.1615/CritRevImmunol.2021040076.
6
Role of Autophagy in Lung Inflammation.自噬在肺部炎症中的作用。
Front Immunol. 2020 Jul 7;11:1337. doi: 10.3389/fimmu.2020.01337. eCollection 2020.
7
Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma.非靶向代谢组学分析鉴定食物过敏和哮喘的疾病特异性特征。
J Allergy Clin Immunol. 2020 Mar;145(3):897-906. doi: 10.1016/j.jaci.2019.10.014. Epub 2019 Oct 25.
8
The role of invariant T cells in inflammation of the skin and airways.不变 T 细胞在皮肤和气道炎症中的作用。
Semin Immunopathol. 2019 May;41(3):401-410. doi: 10.1007/s00281-019-00740-9. Epub 2019 Apr 15.
9
Lipid-Reactive T Cells in Immunological Disorders of the Lung.肺部免疫性疾病中的脂质反应性 T 细胞
Front Immunol. 2018 Sep 26;9:2205. doi: 10.3389/fimmu.2018.02205. eCollection 2018.
10
Role of CD1d- and MR1-Restricted T Cells in Asthma.CD1d-和 MR1 限制的 T 细胞在哮喘中的作用。
Front Immunol. 2018 Aug 28;9:1942. doi: 10.3389/fimmu.2018.01942. eCollection 2018.

本文引用的文献

1
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.先天性免疫反应的持续激活会将呼吸道病毒感染转化为慢性肺病。
Nat Med. 2008 Jun;14(6):633-40. doi: 10.1038/nm1770. Epub 2008 May 18.
2
Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates.自然杀伤T细胞的直接激活会在非人类灵长类动物中诱发气道高反应性。
J Allergy Clin Immunol. 2008 May;121(5):1287-9. doi: 10.1016/j.jaci.2008.02.006. Epub 2008 Mar 19.
3
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.在小鼠模型中暴露于臭氧会诱发气道高反应性，这需要自然杀伤T细胞和白细胞介素-17的存在。
J Exp Med. 2008 Feb 18;205(2):385-93. doi: 10.1084/jem.20071507. Epub 2008 Feb 4.
4
Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease.哮喘和慢性阻塞性肺疾病中的不变自然杀伤T细胞
N Engl J Med. 2007 Apr 5;356(14):1410-22. doi: 10.1056/NEJMoa064691.
5
Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma.支气管肺泡灌洗术检测发现，哮喘患者体内的不变自然杀伤T细胞数量并未增加。
J Allergy Clin Immunol. 2007 May;119(5):1274-6. doi: 10.1016/j.jaci.2007.02.021. Epub 2007 Apr 2.
6
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.美国国立心肺血液研究所严重哮喘研究项目对严重哮喘表型的特征描述。
J Allergy Clin Immunol. 2007 Feb;119(2):405-13. doi: 10.1016/j.jaci.2006.11.639.
7
Invariant natural killer T cells in bronchial asthma.支气管哮喘中的不变自然杀伤T细胞
N Engl J Med. 2006 Jun 15;354(24):2613-6; author reply 2613-6. doi: 10.1056/NEJMc066189.
8
CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma.支气管哮喘中的CD4+不变性T细胞受体+自然杀伤T细胞
N Engl J Med. 2006 Mar 16;354(11):1117-29. doi: 10.1056/NEJMoa053614.
9
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells.糖脂激活恒定T细胞受体阳性自然杀伤T细胞足以诱导气道高反应性，且不依赖于传统的CD4阳性T细胞。
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2782-7. doi: 10.1073/pnas.0510282103. Epub 2006 Feb 14.
10
Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model.前沿：在实验性哮喘模型中，不变性Vα14自然杀伤T细胞是变应原诱导的气道炎症和高反应性所必需的。
J Immunol. 2003 Aug 15;171(4):1637-41. doi: 10.4049/jimmunol.171.4.1637.

Natural killer T cells in the lungs of patients with asthma.

作者信息

Matangkasombut Ponpan, Marigowda Gautham, Ervine Aaron, Idris Luaie, Pichavant Muriel, Kim Hye Young, Yasumi Takahiro, Wilson S Brian, DeKruyff Rosemarie H, Faul John L, Israel Elliot, Akbari Omid, Umetsu Dale T

出版信息

J Allergy Clin Immunol. 2009 May;123(5):1181-5. doi: 10.1016/j.jaci.2009.02.013. Epub 2009 Apr 8.

DOI:10.1016/j.jaci.2009.02.013
PMID:19356791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2734957/
Abstract
摘要