在乳腺癌模型中，孕激素受体充当有丝分裂原蛋白激酶的传感器。
Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models.
作者信息
Dressing Gwen E, Hagan Christy R, Knutson Todd P, Daniel Andrea R, Lange Carol A
机构信息
Department of Medicine (Division of Hematology, Oncology, and Transplantation) and Pharmacology, Masonic Cancer Center, University of Minnesota, MMC 806, Minneapolis, Minnesota 55455, USA.
出版信息
Endocr Relat Cancer. 2009 Jun;16(2):351-61. doi: 10.1677/ERC-08-0281. Epub 2009 Apr 8.
Abstract
Progesterone receptors (PR), members of the nuclear receptor superfamily, function as ligand-activated transcription factors and initiators of c-Src kinase and mitogen-activated protein kinase signaling. Bidirectional cross-talk between PR and mitogenic protein kinases results in changes in PR post-translational modification, leading to alterations in PR transcriptional activity and promoter selectivity. PR-induced rapid activation of cytoplasmic protein kinases insures precise regulatory input to downstream cellular processes that are dependent upon nuclear PR, such as cell-cycle progression, and pro-survival signaling. Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models.
摘要
孕酮受体（PR）是核受体超家族的成员，作为配体激活的转录因子以及c-Src激酶和丝裂原活化蛋白激酶信号传导的启动子发挥作用。PR与促有丝分裂蛋白激酶之间的双向串扰导致PR翻译后修饰的变化，进而引起PR转录活性和启动子选择性的改变。PR诱导的细胞质蛋白激酶的快速激活确保了对依赖于核PR的下游细胞过程（如细胞周期进程和促生存信号传导）进行精确的调节输入。在此，我们综述PR与促有丝分裂蛋白激酶之间的相互作用，并讨论特定翻译后修饰对乳腺癌细胞系模型中PR作用的影响。
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本文引用的文献
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Steroids. 2009 Jul;74(7):568-72. doi: 10.1016/j.steroids.2008.12.004. Epub 2008 Dec 24.
2
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Mol Cell Biol. 2008 Dec;28(24):7309-22. doi: 10.1128/MCB.00808-08. Epub 2008 Oct 6.
3
Glucocorticoid receptor phosphorylation differentially affects target gene expression.
Mol Endocrinol. 2008 Aug;22(8):1754-66. doi: 10.1210/me.2007-0219. Epub 2008 May 15.
4
Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes.
J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):150-7. doi: 10.1016/j.jsbmb.2008.01.002. Epub 2008 Jan 19.
5
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.
Mol Endocrinol. 2008 Apr;22(4):823-37. doi: 10.1210/me.2007-0437. Epub 2008 Jan 17.
6
Concepts in sumoylation: a decade on.
Nat Rev Mol Cell Biol. 2007 Dec;8(12):947-56. doi: 10.1038/nrm2293.
7
Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells.
Mol Endocrinol. 2007 Dec;21(12):2890-906. doi: 10.1210/me.2007-0248. Epub 2007 Aug 23.
8
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9
p27KIP-1, cyclin A and cyclin D1 protein expression in ductal carcinoma in situ of the breast: p27KIP-1 correlates with hormone receptor status but not with local recurrence.
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10
Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity.
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