Rabalais Amy G, Walvekar Rohan, Nuss Daniel, McWhorter Andrew, Wood Charles, Fields Robert, Mercante Donald E, Pou Anna M
Department of Otolaryngology and Head Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Laryngoscope. 2009 Jun;119(6):1120-4. doi: 10.1002/lary.20201.
OBJECTIVES/HYPOTHESIS: To review our results with positron emission tomography and computed tomography fusion imaging (PET-CT) surveillance of the postchemoradiotherapy neck in patients with advanced head and neck squamous cell carcinoma.
Retrospective.
Four hundred twenty-eight patients with advanced head and neck squamous cell carcinoma were treated with nonsurgical therapy from September 2002 to March 2007 and followed with post-treatment PET-CT surveillance of the neck. Fifty-two patients meeting inclusion criteria were analyzed. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT were determined.
Ten patients had a positive post-treatment PET-CT for residual neck disease, and 42 patients had negative scans. The NPV and PPV were 100% and 40%, respectively. The sensitivity, specificity, and accuracy were 100%, 87.5%, and 88%, respectively.
Planned neck dissection can be deferred with a negative post-treatment PET-CT. Assuming a complete response at the primary site and a negative PET-CT scan, there may be a role for serial PET-CT surveillance in patients with residual palpable cervical lymphadenopathy. Laryngoscope, 2009.
目的/假设：回顾我们使用正电子发射断层扫描和计算机断层扫描融合成像（PET-CT）对晚期头颈部鳞状细胞癌患者放化疗后颈部进行监测的结果。
回顾性研究。
2002年9月至2007年3月期间，428例晚期头颈部鳞状细胞癌患者接受了非手术治疗，并在治疗后接受颈部PET-CT监测。对符合纳入标准的52例患者进行分析。确定PET-CT的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和准确性。
10例患者治疗后PET-CT显示颈部有残留病灶呈阳性，42例患者扫描结果为阴性。NPV和PPV分别为100%和40%。敏感性、特异性和准确性分别为100%、87.5%和88%。
治疗后PET-CT结果为阴性时可推迟计划性颈部清扫术。假设原发部位完全缓解且PET-CT扫描结果为阴性，对于有可触及的残留颈部淋巴结病的患者，连续PET-CT监测可能有作用。《喉镜》，2009年。
