使用氟代脱氧葡萄糖正电子发射断层扫描对头颈部癌同步放化疗的临床反应进行早期评估。
Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission tomography.
作者信息
Horiuchi Choichi, Taguchi Takahide, Yoshida Takafumi, Nishimura Goshi, Kawakami Mariko, Tanigaki Yuji, Matsuda Hideki, Mikami Yasukazu, Oka Takashi, Inoue Tomio, Tsukuda Mamoru
机构信息
Department of Otorhinolaryngology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
出版信息
Auris Nasus Larynx. 2008 Mar;35(1):103-8. doi: 10.1016/j.anl.2007.05.003. Epub 2007 Sep 6.
OBJECTIVES
The aim of this study is to assess the utility of FDG-PET in the evaluation of therapeutic effects at 4 weeks after the completion of the concurrent chemoradiotherapy (CCR) in patients with head and neck squamous cell carcinoma (HNSCC).
METHODS
Thirty-one patients with previously untreated HNSCC were retrospectively investigated about FDG-PET, CT, MRI and biopsies of the carcinoma before and 4 weeks after the treatment.
RESULTS
The results of pathological examinations after CCR showed 6 residual cases and 25 ones with a pathologically complete response (pCR). The specificity of FDG-PET was 80%, although the sensitivity was limited to 67%.
CONCLUSIONS
FDG-PET has a high specificity but limited sensitivity to discriminate residual cancer from fibrosis or scar at 4 weeks after CCR. FDG-PET at 4 weeks after CCR was too early to perform because of limited sensitivity.
目的
本研究旨在评估氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在头颈部鳞状细胞癌（HNSCC）患者同步放化疗（CCR）结束4周后评估治疗效果中的应用价值。
方法
回顾性研究31例未经治疗的HNSCC患者治疗前及治疗后4周的FDG-PET、CT、MRI及癌组织活检情况。
结果
CCR后病理检查结果显示6例有残留，25例病理完全缓解（pCR）。FDG-PET的特异性为80%，而敏感性仅为67%。
结论
CCR后4周时，FDG-PET鉴别残留癌与纤维化或瘢痕的特异性高，但敏感性有限。由于敏感性有限，CCR后4周进行FDG-PET检查为时过早。
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