通过还原碳-碳键形成实现（±）-5-脱氧独脚金醇的全合成。

Total synthesis of (+/-)-5-deoxystrigol via reductive carbon-carbon bond formation.

作者信息

Shoji Mitsuru, Suzuki Eriko, Ueda Minoru

机构信息

Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.

出版信息

J Org Chem. 2009 May 15;74(10):3966-9. doi: 10.1021/jo9002085.

DOI:10.1021/jo9002085

PMID:19358528

Abstract

The total synthesis of 5-deoxystrigol was successfully carried out via the regioselective coupling reaction between the aluminum ate complex of an alkyne and an epoxide and the two reductive carbon-carbon bond formations in the presence of transition metals as key steps.

摘要

通过炔烃铝酸酯络合物与环氧化物之间的区域选择性偶联反应以及在过渡金属存在下的两个还原碳-碳键形成作为关键步骤，成功实现了5-脱氧独脚金内酯的全合成。