通过分子内氧化二芳基醚形成全合成aspercyclides A 和 B。
Total synthesis of aspercyclides A and B via intramolecular oxidative diaryl ether formation.
机构信息
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
出版信息
Org Lett. 2012 Aug 17;14(16):4290-2. doi: 10.1021/ol3019727. Epub 2012 Aug 7.
PMID:22871235
Abstract
A highly efficient total synthesis of the 11-membered cyclic aspercyclides A (1) and B (2) has been achieved by chemo- and regioselective intramolecular oxidative C-O bond formation from differently substituted diphenols.
摘要
通过对不同取代的二酚进行化学和区域选择性的分子内氧化 C-O 键形成，实现了 11 元环的aspercyclides A（1）和 B（2）的高效全合成。
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