铜催化的活性烯丙基乙酸酯与甘氨酸衍生物的高度对映选择性共轭加成-消除反应
Highly enantioselective Cu-catalyzed conjugate addition-elimination of activated allylic acetates with glycine derivatives.
作者信息
Chen Chun-Gen, Hou Xue-Long, Pu Lin
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Finglin Road, Shanghai 200032, P. R. China.
出版信息
Org Lett. 2009 May 21;11(10):2073-5. doi: 10.1021/ol900439h.
PMID:19358567
Abstract
The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.
摘要
通过使用Cu/P,N-FcPhox作为催化剂，甘氨酸席夫碱与活化的烷基和芳基取代的烯丙基乙酸酯反应，以高收率和高对映选择性得到4-亚烷基谷氨酸衍生物。
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