Shanghai Key Laboratory of Functional Materials Chemistry & School of Pharmacy, East China University of Science and Technology, Shanghai, China, 200237.
Org Lett. 2011 Nov 18;13(22):6010-3. doi: 10.1021/ol202466v. Epub 2011 Oct 18.
A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.
手性二茂铁衍生物 Fc-DHIPOH 作为一种优秀的 N,O-手性配体，用于不对称铜催化甘氨酸衍生物与亚甲基丙二酸酯的 1,4-加成反应。相应的 1,4-加成产物以高达 95%ee 的优异对映选择性获得高产率。
