Socolovschi Cristina, Mediannikov Oleg, Raoult Didier, Parola Philippe
Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS-IRD 6236, WHO Collaborative Center for Rickettsial diseases and other arthropod-borne bacterial diseases, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.
Vet Res. 2009 Mar-Apr;40(2):34. doi: 10.1051/vetres/2009017. Epub 2009 Apr 10.
Spotted fever group Rickettsiae are predominantly transmitted by ticks. Rickettsiae have developed many strategies to adapt to different environmental conditions, including those within their arthropod vectors and vertebrate hosts. The tick-Rickettsiae relationship has been a point of interest for many researchers, with most studies concentrating on the role of ticks as vectors. Unfortunately, less attention has been directed towards the relationship of Rickettsiae with tick cells, tissues, and organs. This review summarizes our current understanding of the mechanisms involved in the relationship between ticks and Rickettsiae and provides an update on the recent methodological improvements that have allowed for comprehensive studies at the molecular level.
斑点热群立克次体主要通过蜱传播。立克次体已发展出许多策略来适应不同的环境条件，包括其节肢动物媒介和脊椎动物宿主内的环境条件。蜱与立克次体的关系一直是许多研究人员感兴趣的点，大多数研究集中在蜱作为媒介的作用上。不幸的是，立克次体与蜱细胞、组织和器官之间的关系较少受到关注。本综述总结了我们目前对蜱与立克次体之间关系所涉及机制的理解，并提供了近期方法学改进的最新情况，这些改进使得在分子水平上进行全面研究成为可能。
