Lee Jonathan H, Dyke Jonathan P, Ballon Douglas, Ciombor Deborah McK, Tung Glenn, Aaron Roy K
Department of Orthopaedic Surgery, Columbia University Medical Center, 622 West 168th Street, PH 1130, New York, NY 10032, USA.
Orthop Clin North Am. 2009 Apr;40(2):249-57. doi: 10.1016/j.ocl.2008.12.003.
Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system.
骨关节炎和缺血性坏死是病因不明的常见临床病症。最近，血管变化被认为与这两种病症的发病机制有关。本文讨论了使用新型无创成像技术作为评估骨灌注以及量化骨关节炎和缺血性坏死中所见差异的一种手段。对我们人类数据的回顾表明，磁共振成像造影剂保留的时间更长，这表明骨关节炎和缺血性坏死区域的灌注减少。使用这种评估骨灌注的无创方法不仅对骨关节炎和缺血性坏死，而且对影响肌肉骨骼系统的其他病症的诊断、预防和治疗都可能有用。
