Befort P, Riviere S, Maran A, Ramos J, Lequellec A
Service de médecine interne A, hôpital Saint-Eloi, CHU de Montpellier, avenue Augustin-Flisches, 34000 Montpellier, France.
Rev Med Interne. 2010 Feb;31(2):167-9. doi: 10.1016/j.revmed.2009.03.014. Epub 2009 Apr 8.
Cryoglobulinemia associated vasculitis is usually related to hepatitis C virus. Clinical features include purpura, glomerulonephritis, or peripheral neuropathy. Intestinal involvement in cryoglobulinemia is rare and has a poor prognosis. It often leads to a therapeutic with immunosupressive drugs. The related immunodepression exposes to a reactivation of cytomegalovirus (CMV) infection that may also be potentially responsible for intestinal injury. We report a 68-year-old man who presented with iterative intestinal perforations secondary to a cryoglobulinemia vasculitis and then to a CMV infection.
冷球蛋白血症相关性血管炎通常与丙型肝炎病毒有关。临床特征包括紫癜、肾小球肾炎或周围神经病变。冷球蛋白血症累及肠道罕见且预后不良。它常导致使用免疫抑制药物进行治疗。相关的免疫抑制会使巨细胞病毒（CMV）感染再激活，这也可能是肠道损伤的潜在原因。我们报告一名68岁男性，他因冷球蛋白血症性血管炎继发反复肠道穿孔，随后又发生CMV感染。
