Podoprigora G I, Abakumova O Iu
Biull Eksp Biol Med. 1976 Aug;82(8):953-6.
The content of cAMP in the phagocytizing macrophages increased, especially in the phagocytosis of live microbes. cAMP formed in phagocytosis was determined in the incubation medium, whereas in the cells its content remained practically unchanged. In the administration of E. coli 055 to the germ-free guinea pigs the concentration of cAMP was found to be increased in the mucosa cells of the small intestine and in the blood serum; this fact indicated that adenylcyclase system participated in the reactions of the interrelations of the microorganisms with the epithelial cells of the smal intestiine.
吞噬性巨噬细胞中cAMP的含量增加，尤其是在吞噬活微生物时。吞噬作用中形成的cAMP在孵育培养基中测定，而细胞内其含量实际上保持不变。给无菌豚鼠施用大肠杆菌055后，发现小肠粘膜细胞和血清中cAMP浓度升高；这一事实表明腺苷酸环化酶系统参与了微生物与小肠上皮细胞相互关系的反应。
