Hamiwka L D, Wirrell E C
Division of Child Neurology, Ohio State University College of Medicine, Columbus, Ohio 43205, USA.
J Child Neurol. 2009 Jun;24(6):734-42. doi: 10.1177/0883073808329527. Epub 2009 Apr 8.
The goal of this review is to discuss the comorbidities reported in specific epilepsy syndromes to examine possible underlying causes or associations and to present data on current therapies for these conditions. Comorbid conditions including cognitive impairment, neuropsychiatric problems, and social difficulties are common in children with epilepsy, and often more disabling than the seizures themselves. Biological factors associated with a greater risk of comorbidity in epilepsy include younger age at seizure onset, cognitive impairment, temporal or frontal lobe onset, and intractability. Social factors correlating with greater risk include lower socioeconomic status, lower parental education level, and poorer family function. These comorbid conditions not only have a significant impact on the child but also are a source of increased stress and burden for families. Increased awareness and early diagnosis of these conditions may affect therapeutic intervention and long-term outcome as well as assist in better understanding of potential risk factors and biological mechanisms.
本综述的目的是讨论特定癫痫综合征中报告的共病情况，以研究可能的潜在病因或关联，并呈现针对这些病症的当前治疗数据。癫痫患儿常见的共病情况包括认知障碍、神经精神问题和社交困难，且这些共病往往比癫痫发作本身更具致残性。与癫痫共病风险较高相关的生物学因素包括癫痫发作起始时年龄较小、认知障碍、颞叶或额叶发作以及难治性。与较高风险相关的社会因素包括社会经济地位较低、父母教育水平较低以及家庭功能较差。这些共病情况不仅对儿童有重大影响，也是家庭压力和负担增加的一个来源。对这些情况的认识提高和早期诊断可能会影响治疗干预和长期预后，同时有助于更好地理解潜在风险因素和生物学机制。
