Takeda Hiroshi, Fuma Shoichi, Miyamoto Kiriko, Yanagisawa Kei, Ishii Nobuyoshi, Kawaguchi Isao, Doi Kazutaka, Melintescu Anca, Galeriu Dan
Research Center for Radiation Protection, National Institute of Radiological Sciences, 9-1 Anagawa-4-chome, Inage-ku, Chiba-shi, Japan.
Health Phys. 2009 May;96(5):587-93. doi: 10.1097/01.HP.0000343153.96089.00.
Biokinetics of radiocarbon (C) in rats during 14 wk of continuous ingestion of C-wheat was investigated to obtain the dosimetric data on organic C ingested as a food. After the start of continuous ingestion of C-wheat, the concentrations of C in both wet and dry tissues gradually increased and showed a tendency towards a steady-state condition for most of the tissues, except adipose tissue. The steady-state condition was observed at 10 wk in the majority of tissues, but was obtained at 3 wk in liver. The steady-state concentrations in wet tissues ranged from about 10% to 40%, and those in dry tissues ranged from about 80% to 100% of the concentration of C in the ingested food. The highest steady-state concentrations in both wet and dry tissues were observed in liver. When compared the concentrations among tissues at the end of 14 wk of continuous ingestion, adipose tissue was the highest in wet tissue and the lowest in dry tissue. From the concentrations of C in wet tissues at the 14th week, the radiation dose rates to individual tissues were estimated. The dose rates were different among the tissues. The highest dose rate was observed in adipose tissue. The next highest dose rates were found in liver and small intestine, while lower doses were measured in testis and lung. The differences in the dose rate among the tissues seemed to be mainly dependent on the variation in the organic content of each tissue.
研究了大鼠连续14周摄入含碳（C）小麦期间放射性碳（C）的生物动力学，以获取作为食物摄入的有机碳的剂量学数据。在开始连续摄入含碳小麦后，湿组织和干组织中的碳浓度逐渐升高，除脂肪组织外，大多数组织都呈现出趋于稳态的趋势。大多数组织在10周时达到稳态，但肝脏在3周时就达到了。湿组织中的稳态浓度约为摄入食物中碳浓度的10%至40%，干组织中的稳态浓度约为摄入食物中碳浓度的80%至100%。湿组织和干组织中稳态浓度最高的都是肝脏。在连续摄入14周结束时比较各组织间的浓度，脂肪组织在湿组织中浓度最高，在干组织中浓度最低。根据第14周时湿组织中的碳浓度，估算了各个组织的辐射剂量率。各组织的剂量率不同。脂肪组织中的剂量率最高。其次是肝脏和小肠中的剂量率较高，而睾丸和肺中的剂量较低。各组织间剂量率的差异似乎主要取决于每个组织有机含量的变化。
