de Macedo Nelson Luiz, do Socorro Ferreira Monteiro Adriana, de Macedo Luís Guilherme Scavone
Department of Diagnosis and Surgery, Periodontics Division, UNESP, São Paulo State University-São José dos Campos Dental School, SP 12245-000, Brazil.
Implant Dent. 2009 Apr;18(2):182-91. doi: 10.1097/ID.0b013e318198e6e3.
The aim of this study was to evaluate the possibility of obtaining guided bone regeneration using a polytetrafluoroethylene (PTFE) nonporous barrier for 2 endosseous implants, partially inserted in tibiae of rabbits.
Histologic characteristics of the interface between titanium implants (one group with titanium plasma-coated implants and the other group with acid-treated surfaces) and of the regenerated bone were also studied. Twenty screw-vent implants were placed in tibiae of 5 male New Zealand rabbits, 2 at the right side and 2 at the left side, protruding 3 mm from the bone level, to create a horizontal bone defect. At the experimental group the implants were protected with a PTFE nonporous barrier, whereas no barriers were used in contralateral implants. Animals were sacrificed 3 months after surgery and biopsy specimens were evaluated histologically and histomorphometrically under light microscopy. Student's t test was used for statistical analysis.
The histologic measurements showed a mean gain in bone height of 2.15 and 2.42 mm for the barrier group and 1.95 and 0.43 mm for the control group, for the titanium plasma-spray and acid-treated implant surfaces, respectively.
The results of the investigation revealed that the placement of implants protruding 3 mm from crestal bone defects may result in vertical bone augmentation using a nonporous PTFE barrier.
本研究的目的是评估使用聚四氟乙烯（PTFE）无孔屏障膜为两枚部分植入兔胫骨的骨内种植体实现引导骨再生的可能性。
还研究了钛种植体（一组为钛等离子喷涂种植体，另一组为酸处理表面种植体）与再生骨之间界面的组织学特征。将20枚带螺纹孔的种植体植入5只雄性新西兰兔的胫骨中，右侧和左侧各植入2枚，种植体从骨面突出3 mm，以形成水平骨缺损。在实验组，种植体用PTFE无孔屏障膜保护，而对侧的种植体不使用屏障膜。术后3个月处死动物，对活检标本进行组织学和组织形态计量学评估，在光学显微镜下观察。采用学生t检验进行统计学分析。
组织学测量结果显示，对于钛等离子喷涂和酸处理种植体表面，屏障膜组的骨高度平均增加2.15和2.42 mm，对照组分别为1.95和0.43 mm。
研究结果表明，从牙槽嵴骨缺损处突出3 mm植入种植体，并使用无孔PTFE屏障膜，可能会导致垂直骨增量。
