Rebollo-Mesa Irene, Ordoñana Juan R
Section of General Psychiatry, Institute of Psychiatry, King's College of London, Strand, London, UK.
Obesity (Silver Spring). 2009 Aug;17(8):1646-7. doi: 10.1038/oby.2009.108. Epub 2009 Apr 9.
We report a study of the moderating role that the number of childbirths has on the genetic and environmental influences on BMI variation. We used a classical twin design with a sample of 704 adult female twins (334 monozygotic and 370 dizygotic). A gene-environment interaction (G x E) model was applied to estimate the moderating effects of childbearing. Results show that age and number of children exert a significant positive main effect on BMI. Furthermore, we found significant moderating effects of childbearing, with a larger number of children associated with an increased sensitivity to environmental factors.
我们报告了一项关于生育次数对体重指数（BMI）变化的遗传和环境影响的调节作用的研究。我们采用经典双生子设计，样本为704名成年女性双胞胎（334对同卵双胞胎和370对异卵双胞胎）。应用基因-环境交互作用（G×E）模型来估计生育的调节作用。结果表明，年龄和子女数量对BMI有显著的正向主效应。此外，我们发现生育有显著的调节作用，子女数量越多，对环境因素的敏感性越高。
