de Klerk J M, van Rijk P P, van Dongen A J, Deenstra M, Bànki J H, van het Schip A D
Department of Nuclear Medicine, University Hospital Utrecht, The Netherlands.
Eur J Nucl Med. 1991;18(5):317-20. doi: 10.1007/BF02285458.
Radionuclide ventriculography is a useful investigation in the evaluation of cardiac function. Generally, in vivo technetium 99m-labelled red blood cells (RBC) yield good quality images in ventriculography. However, it is widely believed that some drugs have an adverse effect on RBC labelling. Zanelli et al. (1987) developed a radiopharmaceutical (technetium 99m bis-diethylphosphinoethanebis-t-butylisocyanide, 99mTc-DEPIC) to obtain better results in patients using such drugs. We undertook a prospective study of 6 patients with cardiovascular and/or pulmonary disease using several kinds of drugs to evaluate imaging of the cardiac blood pool with 99mTc-DEPIC and in vivo labelled 99mTc-RBC. After injection, blood samples were taken, and gated equilibrium blood pool studies were performed. The radiochemical purity of the injected 99mTc-DEPIC varied from 76.4 to 93.6% (mean 86.4%, SD 5.7%). The protein (pre-albumin) binding was 100%. Biological half-life in blood varied from 3.3 to 4.7 h (mean 4.1 h, SD 0.5 h). For 99mTc-RBC no significant blood disappearance was seen for 8 h. The percentage of RBC-bound 99mTc varied from 96.9% to 98.3% (mean 97.0%, SD 0.5%) and was stable for at least 8 h. The heart-to-lung, heart-to-spleen, and heart-to-liver ratios were higher for 99mTc-RBC than for 99mTc-DEPIC. Furthermore, 99mTc-DEPIC showed a significant decline of the ejection fraction with time. Visually, the images with 99mTc-RBC were superior to those with 99mTc-DEPIC, especially a few hours after injection. According to our findings, in vivo labelling of 99mTc-RBC is still the method of choice for routine radionuclide ventriculography.(ABSTRACT TRUNCATED AT 250 WORDS)
放射性核素心室造影术是评估心脏功能的一项有用检查。一般来说，体内用锝99m标记的红细胞（RBC）在心室造影中能产生质量良好的图像。然而，人们普遍认为某些药物会对红细胞标记产生不良影响。扎内利等人（1987年）研发了一种放射性药物（锝99m双二乙膦基乙烷双叔丁基异腈，99mTc - DEPIC），以便在使用此类药物的患者中获得更好的结果。我们对6例患有心血管和/或肺部疾病且使用多种药物的患者进行了一项前瞻性研究，以评估用99mTc - DEPIC和体内标记的99mTc - RBC进行心脏血池成像的情况。注射后采集血样，并进行门控平衡血池研究。注射的99mTc - DEPIC的放射化学纯度在76.4%至93.6%之间（平均86.4%，标准差5.7%）。蛋白质（前白蛋白）结合率为100%。在血液中的生物半衰期在3.3至4.7小时之间（平均4.1小时，标准差0.5小时）。对于99mTc - RBC，8小时内未见明显的血液消失。与红细胞结合的99mTc的百分比在96.9%至98.3%之间（平均97.0%，标准差0.5%），并且至少8小时保持稳定。99mTc - RBC的心脏与肺、心脏与脾脏、心脏与肝脏的比值高于99mTc - DEPIC。此外，99mTc - DEPIC的射血分数随时间显著下降。从视觉上看，99mTc - RBC的图像优于99mTc - DEPIC的图像，尤其是在注射后几小时。根据我们的研究结果，99mTc - RBC的体内标记仍是常规放射性核素心室造影术的首选方法。（摘要截取自250字）
