Brigden G, Zanelli G, Lahiri A, Raftery E
Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex, UK.
Eur J Nucl Med. 1990;16(11):795-9. doi: 10.1007/BF00833013.
A new, single bolus method of in vivo blood pool imaging using a technetium Tc99m phosphine isocyanide complex (DEPIC) which binds to pre-albumin was evaluated in volunteers (n = 4) and patients (n = 20). DEPIC was assessed for its safety and possible drug interactions. Its duration of action and quality of ventriculography were compared with imaging using standard in vivo red cell labelling (PYP) during two 3-h scanning periods 1 week apart. DEPIC had a mean plasma half-life of 3.3 h. The count rate over the left ventricle was initially 42% higher with DEPIC than with PYP. However, removal of DEPIC by the liver resulted in equivalent count rates by 1 h, and by 3 h PYP count rates were 22% higher than DEPIC. Immediately post injection mean (SD) difference in the left ventricular ejection fraction between the two methods was 2.4% (7.7%). Satisfactory DEPIC scans were obtained up to 2 h post injection, but by 3 h there was a mean difference of 13% (11.3%). DEPIC was found to be a safe alternative to red all labelling for blood pool angiography, suitable for routine work. The single bolus methodology and high initial count rates offer improved efficiency and a capability for truly emergency scanning.
使用与前白蛋白结合的锝 Tc99m 膦异氰化物复合物（DEPIC）的一种新的单次推注体内血池成像方法，在志愿者（n = 4）和患者（n = 20）中进行了评估。对 DEPIC 的安全性和可能的药物相互作用进行了评估。在相隔 1 周的两个 3 小时扫描期内，将其作用持续时间和心室造影质量与使用标准体内红细胞标记（PYP）成像进行了比较。DEPIC 的平均血浆半衰期为 3.3 小时。DEPIC 注射后最初左心室的计数率比 PYP 高 42%。然而，肝脏对 DEPIC 的清除导致 1 小时时计数率相当，到 3 小时时 PYP 的计数率比 DEPIC 高 22%。两种方法注射后即刻左心室射血分数的平均（标准差）差异为 2.4%（7.7%）。注射后长达 2 小时可获得满意的 DEPIC 扫描图像，但到 3 小时时平均差异为 13%（11.3%）。发现 DEPIC 是血池血管造影红细胞标记的一种安全替代方法，适用于常规工作。单次推注方法和高初始计数率提高了效率，并具备真正的急诊扫描能力。
