Cakar Zeynep Petek
Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Turkey.
Biotechnol J. 2009 Jul;4(7):992-1002. doi: 10.1002/biot.200800332.
This review discusses metabolic engineering research with an emphasis on evolutionary (whole cell and protein) engineering, which is an inverse metabolic engineering approach. For each section on metabolic, inverse metabolic and evolutionary engineering research, a general review of the major global studies in the literature is made and research examples from Turkey are given and discussed. It is expected that with the rapid development in systems biology and the novel powerful analytical technologies to identify the genetic basis of cellular phenotypes, metabolic and evolutionary engineering research will become widespread and increasingly important in Turkey, following global scientific trends.
本综述讨论了代谢工程研究，重点是进化（全细胞和蛋白质）工程，这是一种逆向代谢工程方法。对于代谢工程、逆向代谢工程和进化工程研究的每个部分，都对文献中的主要全球研究进行了综述，并给出并讨论了来自土耳其的研究实例。随着系统生物学的快速发展以及用于识别细胞表型遗传基础的新型强大分析技术的出现，预计代谢工程和进化工程研究将跟随全球科学趋势，在土耳其得到广泛应用并变得越来越重要。
