Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea.
Trends Biotechnol. 2011 Aug;29(8):370-8. doi: 10.1016/j.tibtech.2011.04.001. Epub 2011 May 10.
Metabolic engineering has contributed significantly to the enhanced production of various value-added and commodity chemicals and materials from renewable resources in the past two decades. Recently, metabolic engineering has been upgraded to the systems level (thus, systems metabolic engineering) by the integrated use of global technologies of systems biology, fine design capabilities of synthetic biology, and rational-random mutagenesis through evolutionary engineering. By systems metabolic engineering, production of natural and unnatural chemicals and materials can be better optimized in a multiplexed way on a genome scale, with reduced time and effort. Here, we review the recent trends in systems metabolic engineering for the production of chemicals and materials by presenting general strategies and showcasing representative examples.
在过去的二十年中，代谢工程极大地促进了各种有价值和大宗商品化学品和材料从可再生资源中的生产。最近，代谢工程通过系统生物学的全球技术、合成生物学的精细设计能力以及通过进化工程的理性-随机诱变的综合利用，已经升级到系统水平（因此，称为系统代谢工程）。通过系统代谢工程，可以在基因组规模上以多路复用的方式更好地优化天然和非天然化学品和材料的生产，从而减少时间和精力。在这里，我们通过介绍一般策略和展示代表性示例，综述了用于化学品和材料生产的系统代谢工程的最新趋势。
