在针对铜绿假单胞菌的两疗程静脉抗生素治疗期间，年轻囊性纤维化患者的肺功能变化。
Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa.
作者信息
Béghin Laurent, Michaud Laurent, Loeuille Guy-André, Wizla-Derambure Nathalie, Sayah Hocine, Sardet Anne, Thumerelle Caroline, Deschildre Antoine, Turck Dominique, Gottrand Frédéric
机构信息
EA 3925, Université Lille 2 Droit et Santé & Division of Gastroenterology, Hepatology and Nutrition, Cystic Fibrosis Center, Lille, France.
出版信息
Pediatr Pulmonol. 2009 May;44(5):464-71. doi: 10.1002/ppul.21017.
BACKGROUND AND AIMS
Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients.
METHODS
Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa. Each parameter was measured every 15 days during 3-6 months.
RESULTS
Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV(1) (P < 0.05).
CONCLUSION
In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT.
背景与目的
囊性纤维化患者（CF）常需反复静脉应用抗生素治疗（IVAT）以对抗铜绿假单胞菌引起的慢性肺部感染。本研究旨在监测CF患者接受IVAT后肺部及营养状况的衰退动力学。
方法
对21例长期定植有铜绿假单胞菌的CF患者（平均年龄±标准差，16±1.9岁；9名男性）进行肺功能、营养状况及体力活动（PA）测定。在3 - 6个月期间，每15天测量一次各项参数。
结果
在两次IVAT的间隔期内，营养状况及PA未发生变化。相反，肺功能恶化，第一秒用力呼气容积（FEV₁）下降了14.6%（P < 0.05）。
结论
在CF患者中，两次IVAT之间肺功能呈进行性下降，而营养状况和PA无明显恶化。
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