Sluyser M, Nouwen T, Hilgers J, Calafat J
Cancer Res. 1977 Jul;37(7 Pt 1):1986-90.
Levels of mammary tumor virus particles (types A and B) and levels of the virus antigen were assayed in hormone-dependent and -independent mammary tumors of GR mice. Various transplant generations of seven separate tumor lines were investigated. The results indicated that the tumors consisted of different cell clones, each of which exhibited a separate progressive expression and subsequent loss of the mammary tumor virus. When the tumors were transplanted, levels of B particles first declined in the hormone-dependent cells, but in later transplant generations, the B particle content of the autonomous cells also dropped. In some tumor lines, this was accompanied by a decrease in viral antigens and/or A particles, but in other lines these concentrations remained high. One tumor line (line V) that remained hormone-dependent throughout nine transplantations was practically devoid of B particles but contained high levels of A particles and mammary tumor antigen.
在GR小鼠的激素依赖性和非依赖性乳腺肿瘤中检测了乳腺肿瘤病毒颗粒（A和B型）水平以及病毒抗原水平。对七个不同肿瘤系的各个移植代进行了研究。结果表明，肿瘤由不同的细胞克隆组成，每个克隆都表现出乳腺肿瘤病毒的单独渐进性表达及随后的丧失。当肿瘤移植时，B颗粒水平在激素依赖性细胞中首先下降，但在随后的移植代中，自主性细胞的B颗粒含量也下降。在一些肿瘤系中，这伴随着病毒抗原和/或A颗粒的减少，但在其他系中这些浓度仍保持较高。一个在九次移植中始终保持激素依赖性的肿瘤系（V系）几乎没有B颗粒，但含有高水平的A颗粒和乳腺肿瘤抗原。
