Lu C, Ning N, Peng D, Ding G, Li K, Yang Y, Lin C
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China.
Neuroscience. 2009 Jul 21;161(4):1008-26. doi: 10.1016/j.neuroscience.2009.04.020. Epub 2009 Apr 11.
Using the structural equation modeling (SEM) method, the present study examined the role of large-scale neural interactions in developmental stuttering while 10 stuttering and nine non-stuttering subjects performed a covert picture-naming task. Results indicated that the connection patterns were significantly different between stuttering and non-stuttering speakers in both omnibus connection pattern and individual connection path coefficient. Specifically, stuttering speakers showed functional disconnection from the left inferior frontal gyrus to the left motor areas, and altered connectivity in the basal ganglia-thalamic-cortical circuit, and abnormal integration of supramodal information across the cerebellum and several frontal-parietal regions. These results indicate that the large-scale dysfunctional neural interactions may be involved in stuttering speakers' difficulties in planning, execution, and self-monitoring of speech motor sequence during word production.
本研究采用结构方程模型（SEM）方法，在10名口吃者和9名非口吃者执行隐蔽图片命名任务时，考察了大规模神经交互在发育性口吃中的作用。结果表明，口吃者和非口吃者在总体连接模式和个体连接路径系数方面的连接模式存在显著差异。具体而言，口吃者表现出从左下额回至左运动区的功能断开，基底神经节 - 丘脑 - 皮质回路的连接性改变，以及跨小脑和几个额顶叶区域的超模式信息整合异常。这些结果表明，大规模功能失调的神经交互可能与口吃者在单词生成过程中言语运动序列的计划、执行和自我监测困难有关。
