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口吃作为一种谱系障碍:一种假说。

Stuttering as a spectrum disorder: A hypothesis.

作者信息

SheikhBahaei Shahriar, Millwater Marissa, Maguire Gerald A

机构信息

Neuron-Glia Signaling and Circuits Unit, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, 20892, MD, USA.

CenExel Research/ American University of Health Sciences, Signal Hill, CA, 90755, USA.

出版信息

Curr Res Neurobiol. 2023 Nov 1;5:100116. doi: 10.1016/j.crneur.2023.100116. eCollection 2023.

Abstract

Childhood-onset fluency disorder, commonly referred to as stuttering, affects over 70 million adults worldwide. While stuttering predominantly initiates during childhood and is more prevalent in males, it presents consistent symptoms during conversational speech. Despite these common clinical manifestations, evidence suggests that stuttering, may arise from different etiologies, emphasizing the need for personalized therapy approaches. Current research models often regard the stuttering population as a singular, homogenous group, potentially overlooking the inherent heterogeneity. This perspective consolidates both historical and recent observations to emphasize that stuttering is a heterogeneous condition with diverse causes. As such, it is crucial that both therapeutic research and clinical practices consider the potential for varied etiologies leading to stuttering. Recognizing stuttering as a spectrum disorder embraces its inherent variability, allowing for a more nuanced categorization of individuals based on the underlying causes. This perspective aligns with the principles of precision medicine, advocating for tailored treatments for distinct subgroups of people who stutter, ultimately leading to personalized therapeutic approaches.

摘要

儿童期起病的流畅性障碍,通常称为口吃,影响着全球超过7000万成年人。虽然口吃主要在儿童期开始,且在男性中更为普遍,但在对话中会表现出一致的症状。尽管有这些常见的临床表现,但有证据表明,口吃可能由不同的病因引起,这强调了个性化治疗方法的必要性。当前的研究模型通常将口吃人群视为一个单一的、同质的群体,可能忽略了其内在的异质性。这一观点综合了历史和近期的观察结果,强调口吃是一种病因多样的异质性疾病。因此,治疗研究和临床实践都必须考虑到导致口吃的病因可能各不相同。将口吃视为一种谱系障碍,承认其内在的变异性,有助于根据潜在病因对个体进行更细致的分类。这一观点与精准医学的原则相一致,主张为不同的口吃亚组人群提供量身定制的治疗,最终实现个性化的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efa4/10663130/82a792430fcd/gr1.jpg

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