重新探究口吃者言语产生所涉及的神经基础：一项激活可能性估计元分析
Reinvestigating the Neural Bases Involved in Speech Production of Stutterers: An ALE Meta-Analysis.
作者信息
Zhang Ning, Yin Yulong, Jiang Yuchen, Huang Chenxu
机构信息
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Brain Sci. 2022 Aug 3;12(8):1030. doi: 10.3390/brainsci12081030.
BACKGROUND
Stuttering is characterized by dysfluency and difficulty in speech production. Previous research has found abnormalities in the neural function of various brain areas during speech production tasks. However, the cognitive neural mechanism of stuttering has still not been fully determined.
METHOD
Activation likelihood estimation analysis was performed to provide neural imaging evidence on neural bases by reanalyzing published studies.
RESULTS
Our analysis revealed overactivation in the bilateral posterior superior temporal gyrus, inferior frontal gyrus, medial frontal gyrus, precentral gyrus, postcentral gyrus, basal ganglia, and cerebellum, and deactivation in the anterior superior temporal gyrus and middle temporal gyrus among the stutterers. The overactivated regions might indicate a greater demand in feedforward planning in speech production, while the deactivated regions might indicate dysfunction in the auditory feedback system among stutterers.
CONCLUSIONS
Our findings provide updated and direct evidence on the multi-level impairment (feedforward and feedback systems) of stutterers during speech production and show that the corresponding neural bases were differentiated.
背景
口吃的特征是言语不流畅和言语产生困难。先前的研究发现，在言语产生任务期间，各个脑区的神经功能存在异常。然而，口吃的认知神经机制仍未完全确定。
方法
通过重新分析已发表的研究，进行激活可能性估计分析，以提供关于神经基础的神经影像学证据。
结果
我们的分析显示，口吃者的双侧后颞上回、额下回、额内侧回、中央前回、中央后回、基底神经节和小脑存在过度激活，而前颞上回和颞中回存在失活。过度激活的区域可能表明言语产生过程中前馈计划的需求更大，而失活区域可能表明口吃者的听觉反馈系统存在功能障碍。
结论
我们的研究结果为口吃者在言语产生过程中的多层次损伤（前馈和反馈系统）提供了最新的直接证据，并表明相应的神经基础存在差异。
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