Rowland N E
Department of Psychology, University of Florida, Gainesville 32611-2065.
Dev Psychobiol. 1991 Apr;24(3):211-8. doi: 10.1002/dev.420240306.
Fischer 344 (F344) rats and Syrian hamsters, unlike rats of the Sprague-Dawley or Wistar strains, exhibit an aversion to dilute NaCl solutions as adults. In the present studies, using the anterior intraoral infusion method, it is shown that both F344 rats and hamsters accept more dilute NaCl than either water or concentrated NaCl (i.e., show a "single bottle" preference/aversion function identical to Sprague-Dawley rats) at both 6 and 18 days of age. At 18 days of age, they also show a preference for dilute NaCl over water in a simultaneous choice paradigm. In contrast, only 1-3 days later when these animals are weaned, they strongly reject NaCl solutions from sipper tubes in favor of water. It is unlikely that an abrupt discontinuity in neurosensory development can fully explain this dramatic reversal in salt acceptance.
与斯普拉格-道利或威斯塔大鼠品系不同，费希尔344（F344）大鼠和叙利亚仓鼠成年后对稀释的氯化钠溶液表现出厌恶。在本研究中，采用口腔前部输注法，结果显示，在6日龄和18日龄时，F344大鼠和仓鼠接受的稀释氯化钠比水或浓缩氯化钠更多（即表现出与斯普拉格-道利大鼠相同的“单瓶”偏好/厌恶功能）。在18日龄时，它们在同时选择范式中也表现出对稀释氯化钠比对水的偏好。相比之下，仅在这些动物断奶1 - 3天后，它们就强烈拒绝吸管中的氯化钠溶液而选择水。神经感觉发育的突然中断不太可能完全解释这种对盐接受度的戏剧性逆转。
