Sollars S I, Sollars P J, Bernstein I L
Department of Psychology, University of Washington, Seattle 98195.
Behav Neurosci. 1991 Aug;105(4):603-5. doi: 10.1037//0735-7044.105.4.603.
Fischer 344 (F344) rats are atypical in their lack of preference for any concentration of NaCl solution over water. It was hypothesized that abnormal signals mediated by the chorda tympani nerve (CT) could be causally involved in NaCl avoidance by F344 rats. This study assessed whether CT transection would normalize the salt preference of F344 rats. Preference for NaCl solutions (0.6%, 0.8%, and 1.0%) versus water was assessed using two-bottle preference tests. At all concentrations tested, CT-transected animals preferred NaCl solutions to water. This preference differed dramatically from the avoidance of these solutions by controls. These findings are striking, particularly because CT transections have generally failed to significantly affect NaCl preference in other rat strains. The results are consistent with the hypothesis that in F344 rats the avoidance of the taste of NaCl stems from input mediated by the CT.
费希尔344（F344）大鼠不偏好任何浓度的氯化钠溶液而非水，这一点很不寻常。据推测，鼓索神经（CT）介导的异常信号可能是F344大鼠回避氯化钠的原因。本研究评估了切断CT是否会使F344大鼠的盐偏好恢复正常。使用双瓶偏好测试评估对氯化钠溶液（0.6%、0.8%和1.0%）与水的偏好。在所有测试浓度下，切断CT的动物更喜欢氯化钠溶液而非水。这种偏好与对照组对这些溶液的回避形成了显著差异。这些发现令人惊讶，特别是因为切断CT通常未能显著影响其他大鼠品系的氯化钠偏好。结果与以下假设一致，即在F344大鼠中，对氯化钠味道的回避源于CT介导的输入。
