Calter Michael A, Wang Jun
Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459, USA.
Org Lett. 2009 May 21;11(10):2205-8. doi: 10.1021/ol900586f.
Newly synthesized cinchona alkaloid-derived pyrimidines function as effective asymmetric catalysts for the Michael reaction between cyclic diketones and beta,gamma-unsaturated alpha-ketoesters. The reactions of electrophiles with either aryl or alkyl gamma-substituents give 64-99% yields and 94-99% ee.
新合成的金鸡纳生物碱衍生的嘧啶可作为有效的不对称催化剂，用于环状二酮与β,γ-不饱和α-酮酯之间的迈克尔反应。亲电试剂与芳基或烷基γ-取代基的反应产率为64-99%，对映体过量值为94-99%。
