与其他抗惊厥药物相比，丙戊酸钠治疗儿童的氨和肉碱浓度。

Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs.

作者信息

Thom H, Carter P E, Cole G F, Stevenson K L

机构信息

Department of Child Health, University of Aberdeen, Medical School, Foresterhill.

出版信息

Dev Med Child Neurol. 1991 Sep;33(9):795-802. doi: 10.1111/j.1469-8749.1991.tb14963.x.

DOI:10.1111/j.1469-8749.1991.tb14963.x

PMID:1936631

Abstract

Plasma ammonia was measured in 59 children requiring anticonvulsant drugs: 37 children (group 1) on sodium valproate alone or in combination with other drugs and 22 children (group 2) on drugs other than sodium valproate. Plasma ammonia was higher in group 1 children. Total and free carnitine was measured in plasma and erythrocytes of all children and in the urine of 16 children from group 1 and eight from group 2. Plasma and erythrocyte free carnitine was significantly lower in the children on sodium valproate, along with a significant increase in the ratio of acyl (bound) carnitine to free carnitine. No significant correlation was found between plasma ammonia and carnitine concentrations for either group of children. Plasma and erythrocyte concentrations were not related. Urinary free carnitine was reduced in children treated with valproate, with a significant increase in the ratio of bound to free carnitine. Carnitine supplementation is discussed.

摘要

对59名需要使用抗惊厥药物的儿童进行了血浆氨测定：37名儿童（第1组）单独使用丙戊酸钠或与其他药物联合使用，22名儿童（第2组）使用丙戊酸钠以外的药物。第1组儿童的血浆氨水平较高。对所有儿童的血浆和红细胞以及第1组的16名儿童和第2组的8名儿童的尿液进行了总肉碱和游离肉碱测定。使用丙戊酸钠的儿童血浆和红细胞游离肉碱显著降低，同时酰基（结合）肉碱与游离肉碱的比值显著增加。两组儿童的血浆氨和肉碱浓度之间均未发现显著相关性。血浆和红细胞浓度无关。丙戊酸盐治疗的儿童尿游离肉碱减少，结合肉碱与游离肉碱的比值显著增加。文中讨论了肉碱补充问题。