Tenhündfeld Jörg, Wefstaedt Patrick, Nolte Ingo J A
Small Animal Clinic, University of Veterinary Medicine, D-30173 Hanover, Germany.
J Am Vet Med Assoc. 2009 Apr 15;234(8):1031-7. doi: 10.2460/javma.234.8.1031.
To investigate the effects of benazepril and heparin on renal function and blood pressure in dogs with chronic kidney disease.
Randomized controlled clinical trial.
26 dogs with chronic kidney disease.
Dogs were randomly assigned to receive benazepril hydrochloride (0.5 mg/kg [0.23 mg/lb], PO, q 24 h; n = 10), benazepril and heparin (150 U/kg [68 U/lb], SC, q 8 h, for the first 6 days; 10), or a placebo (6) and were followed up for 180 days.
Health status score at the end of the study (ie, day 180) was significantly higher for dogs in the 2 treatment groups than for dogs in the placebo group. In addition, glomerular filtration rate was significantly increased and the urine protein-to-creatinine ratio was significantly decreased, compared with baseline rates, at the end of the study for dogs in both treatment groups but not for dogs in the placebo group. Systolic and diastolic blood pressures were significantly decreased on day 6 for dogs in both treatment groups.
Results suggested that administration of benazepril had beneficial effects in dogs with chronic kidney disease but that short-term administration of heparin in conjunction with benazepril did not appear to provide any additional benefit.
研究贝那普利和肝素对慢性肾病犬肾功能和血压的影响。
随机对照临床试验。
26只慢性肾病犬。
将犬随机分为三组，分别接受盐酸贝那普利（0.5mg/kg[0.23mg/lb]，口服，每24小时一次；n = 10）、贝那普利和肝素（150U/kg[68U/lb]，皮下注射，每8小时一次，持续6天；n = 10）或安慰剂（n = 6），并随访180天。
在研究结束时（即第180天），两个治疗组犬的健康状况评分显著高于安慰剂组犬。此外，与基线水平相比，两个治疗组犬在研究结束时肾小球滤过率显著升高，尿蛋白肌酐比显著降低，而安慰剂组犬则无此变化。两个治疗组犬在第6天时收缩压和舒张压均显著降低。
结果表明，贝那普利对慢性肾病犬有有益作用，但短期联合使用肝素与贝那普利似乎并未提供任何额外益处。
