Cortadellas O, Talavera J, Fernández del Palacio M J
Clínica Veterinaria Germanías, Gandía-Valencia, Spain.
J Vet Intern Med. 2014 Jan-Feb;28(1):30-7. doi: 10.1111/jvim.12246. Epub 2013 Dec 26.
Angiotensin-converting enzyme inhibitors (ACEIs) are currently used to control proteinuria in dogs with chronic kidney disease. Renal diets (RDs) have beneficial effects in the management of azotemic dogs, but its role in proteinuric non-azotemic (PNAz) dogs has been poorly documented.
Administration of a RD to PNAz dogs treated with benazepril (Be) improves proteinuria control compared with the administration of a maintenance diet (MD).
Twenty-two PNAz (urine protein/creatinine ratio [UPC] >1) dogs.
Randomized open label clinical trial design. Dogs were assigned to group-MD (5.5 g protein/100 kcal ME)/Be or to group-RD (3.7 g protein/100 kcal ME)/Be group during 60 days. Dogs with serum albumin (Alb) <2 g/dL received aspirin (1 mg/kg/12 hours). A physical examination, systolic blood pressure (SBP) measurement, complete blood count (CBC), biochemistry panel, urinalysis, and UPC were performed at day 0 (D0) and day 60 (D60).
At D0, there were no significant differences between groups in the evaluated variables. During the study, logUPC (geometric mean (95% CI) and SBP (mean±SD mmHg) significantly decreased (paired t-test, P = 0.001) in Group-RD (logUPC(D0) = 3.16[1.9-5.25]; UPC(D60) = 1.20 [0.59-2.45]; SBP(D0) = 160 ± 17.2; SBP(D60) = 151 ± 15.8), but not in Group-MD (UPC(D0) = 3.63[2.69-4.9]; UPC(D60) = 2.14 [0.76-6.17]; SBP(D0) = 158 ± 14.7; SBP(D60) = 153 ± 11.5). However, RM-ANOVA test did not confirm that changes were consequence of dietary modification. Weight and Alb concentration did not change significantly in any group.
The administration of a RD to PNAz dogs treated with Be might help to control proteinuria and SBP compared with the administration of a MD, without inducing clinically detectable malnutrition, but more studies are warranted.
血管紧张素转换酶抑制剂（ACEIs）目前用于控制患有慢性肾病的犬的蛋白尿。肾脏专用日粮（RDs）对氮质血症犬的管理具有有益作用，但其在非氮质血症蛋白尿（PNAz）犬中的作用鲜有文献记载。
与给予维持日粮（MD）相比，对接受贝那普利（Be）治疗的PNAz犬给予RD可改善蛋白尿控制。
22只PNAz（尿蛋白/肌酐比值[UPC]＞1）犬。
随机开放标签临床试验设计。犬在60天内被分配至MD组（5.5克蛋白质/100千卡代谢能）/Be组或RD组（3.7克蛋白质/100千卡代谢能）/Be组。血清白蛋白（Alb）＜2克/分升的犬接受阿司匹林（1毫克/千克/12小时）治疗。在第0天（D0）和第60天（D60）进行体格检查、收缩压（SBP）测量、全血细胞计数（CBC）、生化指标检测、尿液分析和UPC检测。
在D0时，各评估变量在组间无显著差异。在研究期间，RD组的logUPC（几何平均数（95%可信区间））和SBP（平均值±标准差毫米汞柱）显著降低（配对t检验，P = 0.001）（logUPC（D0） = 3.16[1.9 - 5.25]；UPC（D60） = 1.20 [0.59 - 2.45]；SBP（D0） = 160 ± 17.2；SBP（D60） = 151 ± 15.8），而MD组未降低（UPC（D0） = 3.63[2.69 - 4.9]；UPC（D60） = 2.14 [0.76 - 6.17]；SBP（D0） = 1
