Brittain J-S, Green A L, Jenkinson N, Ray N J, Holland P, Stein J F, Aziz T Z, Davies P
Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, OX3 9DU,UK.
Cephalalgia. 2009 Nov;29(11):1165-73. doi: 10.1111/j.1468-2982.2009.01846.x. Epub 2009 Apr 2.
Cluster headache (CH) is a debilitating neurovascular condition characterized by severe unilateral periorbital head pain. Deep brain stimulation of the posterior hypothalamus has shown potential in alleviating CH in its most severe, chronic form. During surgical implantation of stimulating macroelectrodes for cluster head pain, one of our patients suffered a CH attack. During the attack local field potentials displayed a significant increase in power of approximately 20 Hz. To the authors' knowledge, this is the first recorded account of neuronal activity observed during a cluster attack. Our results both support and extend the current literature, which has long implicated hypothalamic activation as key to CH generation, predominantly through indirect haemodynamic neuroimaging techniques. Our findings reveal a potential locus in CH neurogenesis and a potential rationale for efficacious stimulator titration.
丛集性头痛（CH）是一种使人衰弱的神经血管疾病，其特征为单侧眼眶周围严重头痛。对下丘脑后部进行深部脑刺激已显示出对缓解最严重的慢性丛集性头痛具有潜力。在为丛集性头痛患者手术植入刺激大电极的过程中，我们的一名患者遭遇了一次丛集性头痛发作。发作期间，局部场电位显示约20赫兹的功率显著增加。据作者所知，这是首次记录到丛集性头痛发作期间观察到的神经元活动。我们的结果既支持又扩展了当前的文献，长期以来，这些文献主要通过间接血流动力学神经成像技术暗示下丘脑激活是丛集性头痛发作的关键。我们的发现揭示了丛集性头痛神经发生的一个潜在部位以及有效刺激器滴定的潜在理论依据。
