Department of Neurosurgery, Fondazione Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Neurol Sci. 2012 May;33 Suppl 1:S131-5. doi: 10.1007/s10072-012-1057-2.
Neuromodulation for the treatment of drug-refractory cranial neuralgias constitutes an exciting field of research for physicians; in the last decade, several methodologies have been described which could help many patients to exit such desperate conditions; although the exact mechanisms of action of these techniques are still matter of debate, several experimental and neuroradiological modalities can help us to get near the concept of understanding them. In this paper, the authors summarize the most recent surgical procedures used to treat severe and pharmaco-resistant cranial painful conditions, along with brief descriptions of the results obtained in the several published so far.
神经调节治疗药物难治性颅神经痛是医生研究的一个令人兴奋的领域；在过去的十年中，已经描述了几种方法，这些方法可以帮助许多患者摆脱这种绝望的状况；尽管这些技术的确切作用机制仍存在争议，但几种实验和神经影像学方法可以帮助我们更好地理解这些技术。本文作者总结了目前用于治疗严重和药物难治性颅部疼痛疾病的最新手术方法，并简要描述了迄今为止已发表的多项研究的结果。
