Tydén G, Tibell A, Bolinder J, Ostman J, Groth C G
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
Diabetologia. 1991 Aug;34 Suppl 1:S21-3. doi: 10.1007/BF00587613.
Between April 1974 and June 1990, 128 pancreatic transplantations were performed. Of these 117 were with pancreatico-enterostomy. In four consecutive series of combined transplantations in uraemic diabetic patients the 1-year graft survival rate have successively improved (27%, 65%, 68% and 73%). In three similar series of single pancreatic transplantations the results also improved but still remained inferior (0%, 33% and 33%). In a series of combined transplantations performed in preuraemic diabetic patients the 1-year actuarial graft survival rate was only 25%. The results with pancreatic transplantation with pancreatico-enterostomy are now satisfactory. However, immunological loss graft function still constitute a major problem in the non- or pre-uraemic recipients. The metabolic control in patients with functioning grafts is normal or near-normal in the majority of patients followed for at least 1 year.
1974年4月至1990年6月期间，共进行了128例胰腺移植手术。其中117例采用胰肠吻合术。在对尿毒症糖尿病患者进行的连续四组联合移植手术中，1年移植物存活率相继提高（分别为27%、65%、68%和73%）。在三组类似的单纯胰腺移植手术中，结果也有所改善，但仍较低（分别为0%、33%和33%）。在对尿毒症前期糖尿病患者进行的一组联合移植手术中，1年实际移植物存活率仅为25%。目前，采用胰肠吻合术的胰腺移植结果令人满意。然而，免疫性移植物功能丧失在非尿毒症或尿毒症前期受者中仍然是一个主要问题。在大多数至少随访1年的有功能移植物的患者中，代谢控制正常或接近正常。
