Tydén G, Brattström C, Lundgren G, Ostman J, Gunnarsson R, Groth C G
Transplantation. 1987 May;43(5):674-6. doi: 10.1097/00007890-198705000-00014.
Twenty eight consecutive combined renal and pancreatic transplantations with enteric exocrine diversion were performed between June 1984 and May 1986. The one-year actuarial patient survival and renal and pancreatic graft survival were 90%, 67%, and 69%, respectively. Nineteen pancreatic grafts and eighteen renal grafts are currently functioning at 1-24 months. Of the pancreatic graft losses only 2 were attributable to nonimmunological complications. No pancreatic graft was lost due to pancreaticoenteric leakage or vascular thrombosis. This was achieved by reducing the cold ischemia time and by adopting an aggressive anticoagulant policy. In all patients with functioning grafts the fasting blood glucose, glycosylated hemoglobin level, and oral glucose tolerance test were normal. The intravenous glucose tolerance test was normal in most of the patients but subnormal in some.
1984年6月至1986年5月期间，连续进行了28例联合肾脏和胰腺移植，并采用肠道外分泌转流术。患者1年预期生存率、肾脏和胰腺移植存活率分别为90%、67%和69%。目前，19个胰腺移植物和18个肾脏移植物在1 - 24个月内仍在发挥功能。在胰腺移植物丢失中，仅有2例归因于非免疫性并发症。没有胰腺移植物因胰肠吻合口漏或血管血栓形成而丢失。这是通过缩短冷缺血时间和采取积极的抗凝策略实现的。在所有移植功能良好的患者中，空腹血糖、糖化血红蛋白水平和口服葡萄糖耐量试验均正常。大多数患者的静脉葡萄糖耐量试验正常，但有些患者低于正常水平。
