Kramer Caroline Kaercher, von Mühlen Denise, Jassal Simerjot Kaur, Barrett-Connor Elizabeth
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Diabetes Care. 2009 Jul;32(7):1272-3. doi: 10.2337/dc09-0275. Epub 2009 Apr 14.
To determine whether serum uric acid predicts incident type 2 diabetes by glucose tolerance status in older community-dwelling adults.
Participants without diabetes at baseline were evaluated for incident type 2 diabetes 13 years later. Baseline glucose tolerance status was defined as normoglycemia, impaired fasting glucose, and impaired postchallenge glucose tolerance.
A total of 566 participants were included (mean age 63.3 +/- 8.6 years; 41% men). Regression models adjusted for age, sex, BMI, diuretic use, and estimated glomerular filtration rate showed that for each 1 mg/dl increment in uric acid levels, incident type 2 diabetes risk increased by approximately 60%. When analyses were stratified by glucose status, uric acid levels independently predicted incident type 2 diabetes among participants who had impaired fasting glucose (odds ratio 1.75, 95% CI 1.1-2.9, P = 0.02).
Uric acid may be a useful predictor of type 2 diabetes in older adults with impaired fasting glucose.
确定在社区居住的老年成年人中，血清尿酸是否可根据葡萄糖耐量状态预测2型糖尿病的发病情况。
对基线时无糖尿病的参与者进行评估，以确定13年后2型糖尿病的发病情况。基线葡萄糖耐量状态定义为血糖正常、空腹血糖受损和糖耐量受损。
共纳入566名参与者（平均年龄63.3±8.6岁；41%为男性）。经年龄、性别、体重指数、利尿剂使用情况和估计肾小球滤过率校正的回归模型显示，尿酸水平每增加1mg/dl，2型糖尿病发病风险约增加60%。按血糖状态分层分析时，尿酸水平可独立预测空腹血糖受损参与者的2型糖尿病发病情况（比值比1.75，95%置信区间1.1 - 2.9，P = 0.02）。
尿酸可能是空腹血糖受损老年成年人2型糖尿病的有用预测指标。
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