Lindsey Jason B, de Lemos James A, Cipollone Francesco, Ayers Colby R, Rohatgi Anand, Morrow David A, Khera Amit, McGuire Darren K
Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Diabetes Care. 2009 Jul;32(7):1218-20. doi: 10.2337/dc09-0053. Epub 2009 Apr 14.
To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis.
Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging and sRAGE data.
An inverse graded association was observed between sRAGE quartiles and CAC, with CAC prevalence of 28.5% in quartile 1 compared with 15.7% in quartile 4 (P < 0.0001). After multivariable adjustment, the associations between sRAGE levels in the first and second quartiles (versus fourth quartile) and CAC remained statistically significant (adjusted odds ratio 1.71 [95% CI 1.2-2.4] and 1.5 [1.0-2.1], respectively).
sRAGE is a novel biomarker that is inversely associated with coronary atherosclerosis. The role of sRAGE in the pathobiology of atherosclerosis and its potential prognostic and therapeutic implications warrant further investigation.
确定循环晚期糖基化终产物可溶性受体（sRAGE）与冠状动脉粥样硬化之间的关联。
利用达拉斯心脏研究（一项基于概率的人群样本研究）的数据，在2571名有完整成像和sRAGE数据的受试者中评估sRAGE血浆水平与冠状动脉钙化（CAC）之间的关联。
观察到sRAGE四分位数与CAC之间呈反向分级关联，四分位数1中CAC患病率为28.5%，而四分位数4中为15.7%（P<0.0001）。多变量调整后，第一和第二四分位数（与第四四分位数相比）的sRAGE水平与CAC之间的关联仍具有统计学意义（调整后的优势比分别为1.71[95%CI 1.2 - 2.4]和1.5[1.0 - 2.1]）。
sRAGE是一种与冠状动脉粥样硬化呈负相关的新型生物标志物。sRAGE在动脉粥样硬化病理生物学中的作用及其潜在的预后和治疗意义值得进一步研究。
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