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低碳水化合物饮食与低脂饮食为期1年的饮食干预对2型糖尿病患者体重和血糖控制影响的比较研究

Comparative study of the effects of a 1-year dietary intervention of a low-carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes.

作者信息

Davis Nichola J, Tomuta Nora, Schechter Clyde, Isasi Carmen R, Segal-Isaacson C J, Stein Daniel, Zonszein Joel, Wylie-Rosett Judith

机构信息

Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA.

出版信息

Diabetes Care. 2009 Jul;32(7):1147-52. doi: 10.2337/dc08-2108. Epub 2009 Apr 14.

DOI:10.2337/dc08-2108
PMID:19366978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2699720/
Abstract

OBJECTIVE: To compare the effects of a 1-year intervention with a low-carbohydrate and a low-fat diet on weight loss and glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This study is a randomized clinical trial of 105 overweight adults with type 2 diabetes. Primary outcomes were weight and A1C. Secondary outcomes included blood pressure and lipids. Outcome measures were obtained at 3, 6, and 12 months. RESULTS: The greatest reduction in weight and A1C occurred within the first 3 months. Weight loss occurred faster in the low-carbohydrate group than in the low-fat group (P = 0.005), but at 1 year a similar 3.4% weight reduction was seen in both dietary groups. There was no significant change in A1C in either group at 1 year. There was no change in blood pressure, but a greater increase in HDL was observed in the low-carbohydrate group (P = 0.002). CONCLUSIONS: Among patients with type 2 diabetes, after 1 year a low-carbohydrate diet had effects on weight and A1C similar to those seen with a low-fat diet. There was no significant effect on blood pressure, but the low-carbohydrate diet produced a greater increase in HDL cholesterol.

摘要

目的：比较为期1年的低碳水化合物饮食和低脂饮食干预对2型糖尿病患者体重减轻及血糖控制的影响。 研究设计与方法：本研究是一项针对105名超重2型糖尿病成年患者的随机临床试验。主要结局指标为体重和糖化血红蛋白（A1C）。次要结局指标包括血压和血脂。在3个月、6个月和12个月时获取结局测量值。 结果：体重和A1C的最大降幅出现在前3个月内。低碳水化合物组的体重减轻速度比低脂组更快（P = 0.005），但在1年时，两个饮食组的体重均有相似的3.4%的减轻。1年时两组的A1C均无显著变化。血压无变化，但低碳水化合物组的高密度脂蛋白（HDL）升高幅度更大（P = 0.002）。 结论：在2型糖尿病患者中，1年后低碳水化合物饮食对体重和A1C的影响与低脂饮食相似。对血压无显著影响，但低碳水化合物饮食使HDL胆固醇升高幅度更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c21/2699720/ccb564f1235b/zdc0070976270001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c21/2699720/ccb564f1235b/zdc0070976270001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c21/2699720/ccb564f1235b/zdc0070976270001.jpg

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本文引用的文献

[1]
Safety and efficacy of glargine compared with NPH insulin for the treatment of Type 2 diabetes: a meta-analysis of randomized controlled trials.

Diabet Med. 2008-8

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Nutr Metab (Lond). 2006-3-23

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