Passoni F, D'Urbano M, Castelli C, Cafiero F, Seveso G, Spaziani D, Cammelli F, Romano S
Divisione di Cardiologia, Ospedale di Legnano.
G Ital Cardiol. 1991 May;21(5):477-84.
84 patients (pts) with recent first uncomplicated myocardial infarction underwent during the early post-infarction period, dipyridamole (D) test (EKG-ECHO-THALLIUM) and coronary arteriography in order to verify its feasibility, safety and usefulness in the detection of residual jeopardized but viable myocardium and in the diagnosis of multivessel disease. 69 pts performed a pre-discharge exercise test. During the execution of D test no major side effect occurred. The D-Echo was positive for residual ischemia in 41 pts (48.8%), the D-Thallium in 49 pts (58.3%) and the exercise test in 30 pts (43.5%). Both the imaging techniques allow the recognition of viable myocardium within the infarct zone (homozonal positivity) or outside the infarct zone (heterozonal positivity). The sensibility and specificity for multivessel disease are, respectively: with D-echo 50% and 100%; with D-thallium 60% and 100%; with exercise test 48% and 63%. D test has better diagnostic accuracy than exercise test in detecting multivessel disease; in particular we emphasized the excellent specificity of D-echo and D-thallium test. Poliparametric approach with D-test and exercise test gives a better stratification of the ischemic post-infarction risk.
84例近期首次发生无并发症心肌梗死的患者在心肌梗死后早期接受了双嘧达莫(D)试验(心电图-超声心动图-铊扫描)和冠状动脉造影,以验证其在检测残留的濒危但存活心肌以及诊断多支血管病变方面的可行性、安全性和有效性。69例患者进行了出院前运动试验。在进行D试验过程中未出现重大副作用。D-超声心动图显示41例患者(48.8%)存在残余缺血阳性,D-铊扫描显示49例患者(58.3%)阳性,运动试验显示30例患者(43.5%)阳性。两种成像技术都能识别梗死区内(同区域阳性)或梗死区外(异区域阳性)的存活心肌。对于多支血管病变,其敏感性和特异性分别为:D-超声心动图为50%和100%;D-铊扫描为60%和100%;运动试验为48%和63%。在检测多支血管病变方面,D试验比运动试验具有更好的诊断准确性;特别是我们强调了D-超声心动图和D-铊扫描试验的优异特异性。采用D试验和运动试验的多参数方法能更好地对心肌梗死后缺血风险进行分层。