Department of Analytical Chemistry, University of Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
Mass Spectrom Rev. 2010 Sep-Oct;29(5):776-805. doi: 10.1002/mas.20234.
This article reviews recent literature on current methodologies based on chromatography coupled to mass spectrometry to analyze phenolic compounds with endocrine-disrupting capabilities. For this review we chose alkylphenol ethoxylates, bisphenol A, bisphenol F, and their degradation products and halogenated derivatives, which are considered important environmental contaminants. Additionally, some related compounds such as bisphenol diglycidylethers were included. Growing attention has been paid to the mass spectrometric characterization of these compounds and the instrumentation and strategies used for their quantification and confirmation. The current use of gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) methodologies with different mass spectrometers and ionization and monitoring modes is discussed. Practical aspects with regards to the use of these analytical techniques, such as derivatizing reagents in GC-MS, ion suppression in LC-MS, and the most problematic aspects of quantification, are included in the discussion.
本文综述了近年来基于色谱与质谱联用分析具有内分泌干扰能力的酚类化合物的最新文献。本综述选择了烷基酚聚氧乙烯醚、双酚 A、双酚 F 及其降解产物和卤代衍生物，这些物质被认为是重要的环境污染物。此外，还包括了一些相关的化合物，如双酚 A 二缩水甘油醚。人们越来越关注这些化合物的质谱特征，以及用于定量和确证的仪器和策略。本文讨论了不同质谱仪和离子化及监测模式下使用气相色谱-质谱（GC-MS）和液相色谱-质谱（LC-MS）方法的情况。讨论中还包括了使用这些分析技术的实际方面，如 GC-MS 中的衍生试剂、LC-MS 中的离子抑制以及定量方面最具挑战性的问题。
