Suzuki K, Hayashi N, Sasaki Y, Kono M, Imai Y, Fusamoto H, Kamada T
First Department of Medicine, Osaka University Medical School, Japan.
Gastroenterology. 1991 Nov;101(5):1325-31. doi: 10.1016/0016-5085(91)90084-x.
To evaluate the morphological changes in chronic liver disease by means of ultrasonography, cepstral analysis was applied to the ultrasonic waveforms obtained with a 10-MHz transducer during peritoneoscopy. Assuming that liver tissue was a collection of semiregularly arrayed small scatters of ultrasound, the spaces between scatterers of the liver could be measured by means of cepstral analysis. From the distribution of the spaces between scatterers, two statistical parameters, mode and kurtosis, were determined for each patient. The mode of spaces between scatterers for liver cirrhosis was significantly larger than that for chronic hepatitis and nonspecific change. The mode of spaces between scatterers was correlated with the size of hepatic lobules or nodules. The kurtosis of spaces between scatterers for chronic hepatitis and liver cirrhosis was significantly smaller than that for nonspecific change. As a preliminary study for noninvasive application of this technique, cepstral analysis was also applied to the ultrasonogram obtained through the abdominal wall with a 3.5-MHz transducer. The results obtained with a 3.5-MHz transducer were correlated well with those obtained with a 10-MHz transducer. These results suggest the possibility of noninvasive evaluation of the structural changes in chronic liver disease.
为通过超声检查评估慢性肝病的形态学变化，在腹腔镜检查期间，对使用10兆赫换能器获得的超声波形应用了倒谱分析。假设肝组织是超声半规则排列的小散射体的集合，肝脏散射体之间的间距可通过倒谱分析来测量。根据散射体之间间距的分布，为每位患者确定了两个统计参数，众数和峰度。肝硬化患者散射体之间的间距众数显著大于慢性肝炎和非特异性改变患者。散射体之间的间距众数与肝小叶或结节的大小相关。慢性肝炎和肝硬化患者散射体之间间距的峰度显著小于非特异性改变患者。作为该技术无创应用的初步研究，倒谱分析也应用于使用3.5兆赫换能器经腹壁获得的超声图像。使用3.5兆赫换能器获得的结果与使用10兆赫换能器获得的结果相关性良好。这些结果提示了无创评估慢性肝病结构变化的可能性。
